The correspondence between lesion formation and GM atrophy distribution varies in the different forms of MS. While in RRMS and SPMS patients there was a correspondence between presence of T2 visible lesions and GM atrophy in several areas, this was not the case in PPMS patients.ĭistinct patterns of regional distribution of GM damage and T2-visible lesions are associated with cognitive impairment in MS patients with different clinical phenotypes. I am excited and honored to introduce this special issue on metabolic brain mapping of brain disorders in the American Journal of Neuroradiology.With the global extension of human life expectancy along with various lifestyle and environmental factors, there has been a dramatic increase in the incidence of various central nervous system disorders. Conversely, compared with CI PPMS, CI SPMS patients had a significant GM loss in several regions of the fronto-temporal lobes, the left hypothalamus and thalami. No areas were significantly more atrophied in CI SPMS vs. Proceedings of the National Academy of Sciences 117 (14), 8115-8125.
RA Ozdemir, E Tadayon, P Boucher, D Momi, KA Karakhanyan, MD Fox. CP MS patients, according to their clinical phenotype. Individualized perturbation of the human connectome reveals reproducible biomarkers of network dynamics relevant to cognition. Different patterns of regional distribution of GM atrophy and T2-visible lesions were found between CI vs. In all MS groups, regional GM loss was correlated with cognitive impairment. The pace at which technology has advanced in the past several decades is staggering. Voxel-wise distribution of GM damage and T2-lesions was compared between cognitively impaired (CI) and cognitively preserved (CP) patients according to their clinical phenotype. The Human Connectome Project and Brain Mapping. Twenty-two relapsing remitting (RR), 29 secondary progressive (SP), and 22 primary progressive (PP) MS patients, and 39 healthy controls underwent high-field structural magnetic resonance imaging and an extensive neuropsychological battery. Brain mapping is a set of neuroscience techniques predicated on the mapping of (biological) quantities or properties onto spatial representations of. To investigate whether cognitive impairment in multiple sclerosis (MS) patients is associated to different patterns of gray matter (GM) atrophy and T2-visible lesion distribution according to the clinical phenotype.